And besides using Anti-EGFR MoAbs, other alternative therapies should also be considered. As current data suggests that evaluation of not only KRAS or BRAF but also P1k3CA/PTEN alterations could be useful for selecting LGK-974 solubility dmso patients with mCRC
who are unlikely to respond to anti Anti-EGFR-MoAbs. Genetic manipulation techniques can be applied to cellular models, one can envisage developing in vitro tools to prospectively find new sensitivity resistance biomarkers that can then be confirmed in patients and even be used to screen for rationale drug combinations to reverse resistance. To restore the sensitivity of MoAbs, they could be administered Inhibitors,research,lifescience,medical along with BRAF inhibitors and at the same time new ways should be found out in order to reduce the resistance to the BRAF inhibitors, further understanding of the molecular mechanisms to discover new alternative therapies and tests for non-responding Inhibitors,research,lifescience,medical patients would be helpful. Acknowledgements Disclosure: The authors declare no conflict of interest.
Peritoneal carcinomatosis (PC) is a challenging problem with poor prognosis. Survival even with the current standard chemotherapy is dismal. Cytoreductive surgery (CRS) and Inhibitors,research,lifescience,medical Hyperthermic intraperitoneal chemotherapy (HIPEC) in appropriately selected
patients may offer significant survival benefit. In the review article entitled “Assessment Inhibitors,research,lifescience,medical of Clinical benefit and quality of life in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for management of peritoneal carcinomatosis” authors provide a comprehensive review Inhibitors,research,lifescience,medical of the
available data related to the morbidity, mortality, survival and quality of life with CRS and HIPEC for the management of peritoneal carcinomatosis (1). Several retrospective studies have shown the feasibility and benefit of CRS and HIPEC in the management of various peritoneal surface malignancies (2,3). Although clinical utility of CRS and HIPEC in the management of mesothelioma and peritoneal dissemination of appendiceal malignancies is widely accepted, its role in colorectal cancer peritoneal carcinomatosis has been heavily debated. Randomized controlled trial by Veerwal Vasopressin Receptor et al. demonstrated a survival benefit of 9 months for patients with colorectal peritoneal carcinomatosis treated with CRS and HIPEC followed by 5-FU chemotherapy compared to palliative surgery and 5-FU chemotherapy (4). Furthermore, patients who underwent complete cytoreduction had a 5-year survival rate of 45%, which favorably compares to the reported survival for colorectal hepatic metastasectomy.