ING5 might be an important target gene of miR-196a. Key Word(s): 1. microRNA; 2. miR-196a; 3. ING5; 4. pancreatic cancer; Presenting Author: JUN TIE Additional Authors: ZHUOLI ZHANG, CHUANGYE HE, ZHANXIN YIN, YANHONG LI, WENGANG GUO, JING NIU, FEIFEI WU, ANDREWC. LARSON, DAIMING FAN, GUOHONG HAN Corresponding Author: JUN TIE, GUOHONG HAN Affiliations: Xijing Hospital of Digestive Disease;

Department of Radiology, Feinberg School of Medicine, Northwestern University; Departments of Radiology and Biomedical Engineering, Northwestern University Objective: This study sought to retrospectively analyze the efficacy and safety of a port-catheter drug delivery system (PCS) implanted via left subclavian artery for Topoisomerase inhibitor gemcitabine administration during the treatment of advanced pancreatic cancer. Methods: Eighty patients with advanced pancreatic cancer who met our inclusion criteria were enrolled in the study and received gemcitabine through a PCS. We retrospectively analyzed the clinical benefit response this website (CBR), tumor

objective response rate (ORR), overall survival (OS), drug toxicity, and surgical complications. Results: The CBR rate was 56.0% (45/80) and mainly manifested as pain relief and reduced analgesic drug use. Among the 80 patients enrolled, 9 cases had a partial response (11.3%), 27 cases had stable disease (33.8%) and 16 cases developed

progressive disease (20.0%). The ORR was 11.3% and the disease control rate was 45.0%. The median survival time was 160 days, and the 1-year survival rate was 23.3%. Univariate and multivariate Cox MCE公司 proportional hazards models for predictors of OS showed that obstructive jaundice, ECOG score, number of chemotherapy treatments, and metastasis were independent factors that affected the prognosis of patients with advanced pancreatic cancer. Drug toxicity manifested mainly as mild bone marrow suppression, nausea, and vomiting. The most common interventional complication was port-catheter blockage (2/80, 2.5%) and catheter tip dislocation (3/80, 3.8%). Conclusion: Interventional chemotherapy via a PCS can significantly increase the CBR of patients, improve quality of life, and reduce systemic toxicity. Thus, this approach can be considered a safe and effective treatment for advanced pancreatic cancer. Key Word(s): 1. pancreatic cancer; 2. PCS; 3. gemcitabine; 4. treatment outcome; Presenting Author: YIQI DU Additional Authors: ZHAOSHEN LI Corresponding Author: YIQI DU Affiliations: Department of Gastroenterology, Changhai Hospital Objective: Detection of pancreatic cancer (PDAC), particularly at early stages, remains a great challenge owing to lack of specific biomarkers.