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“Ionotropic gelation was used to entrap aceclofenac into algino-pectinate bioadhesive microspheres as a potential drug carrier for the oral delivery of this anti-inflammatory drug. Microspheres were investigated in vitro for possible sustained drug release and their use in vivo as a gastroprotective system for aceclofenac. Polymer concentration and polymer/drug ratio were analyzed for their influence on microsphere properties. The microspheres exhibited

good bioadhesive property and showed high drug entrapment efficiency. Drug release profiles exhibited faster release of aceclofenac from Taselisib mw alginate microspheres whereas algino-pectinate microspheres showed prolonged release. Dunnet’s multiple comparison analysis suggested a significant difference in percent inhibition of paw edema when the optimized formulation was compared to pure drug. It was concluded that the algino-pectinate bioadhesive formulations exhibit promising properties of a sustained release form for aceclofenac and that they provide distinct tissue protection in the stomach.”
“OBJECTIVES: To describe chronic obstructive pulmonary disease (COPD) mortality rates in

Andalusia, Spain, between 1975 and 2010 using a joinpoint regression analysis.

DESIGN: Mortality figures for Andalusian residents aged >40 years from 1975 to 2010 this website were obtained from the National Institute of Statistics. Causes of death were classified based on the 8th, 9th and 10th revisions of the International Classification of Diseases. Crude, standardised (SMR) and 40-

to 70-year truncated mortality rates were calculated. Trends were analysed using joinpoint regression analysis to identify significant NVP-HSP990 research buy trend changes, and an annual percentage of change (APC) was computed from each trend.

RESULTS: Mortality rates showed a downward trend for both sexes. The SMR ranged from 109.9 to 98.0 deaths/100000 males, and between 35.8 and 12.0 deaths/100000 females. An increase in the average age at death for men and women with COPD was also observed. Both sexes experienced an increase in SMR in the early 1980s, although female mortality rates began to decline in 1985 (APC -5.8% thereafter), whereas those for males remained high until 1998 (APC -4% thereafter).

CONCLUSIONS: COPD mortality remains higher in male than female inhabitants of Andalusia. These rates have decreased following different sex- and age-dependent patterns.”
“The present study is aimed to develop dextromethorphan hydrobromide (DXM) oral disintegrating tablets (ODT) with acceptable palatability to help patients of all age groups. The bitter taste of the drug was masked by binding the drug to ion exchange resin. The effect of the particle size of resin on drug loading was studied. In vitro and in vivo disintegration time and in vitro drug release studies were performed. Drug loading increased significantly with a decrease in the particle size of the resin.