The GT of P407 based

in situ gel increased with an increase in the P188 concentration. NaHA and C934 lowered the GT of poloxamer analogs based in situ gel. Correlation analysis demonstrated that in vitro drug release from in situ gel was controlled by gel dissolution and followed zero-order kinetics. Tiopronin in vitro transcorneal transit accorded with zero-order kinetics. Twenty-two percent P407 and 6% P188 containing 0.2% NaHA based formulation can be chosen as in situ gel matrix of tiopronin because of proper GT and sustained releasing ability. In vivo study showed that the area under the aqueous humor-concentration time curve of tiopronin increased by 1.6 folds for in situ gel, compared with www.selleckchem.com/products/ABT-263.html tiopronin aqueous solution. High-dose tiopronin in situ gel and solution delayed the development of selenite cataract 6 d and 4 cl, respectively. The results showed

that tiopronin in situ gel exhibits higher bioavailability and therapeutical effect. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 114: 775-783, 2009″
“We report on the surface nanostructuring of silicon wafer by self-organization of redeposited Si nanoparticles, at various energy levels, in the vaporization regime of laser-matter interaction. By using the semiconfined configuration, a quasi-two-dimensional turbulent Si vapor field with gradients of pressure and temperature is formed. The turbulent field evolves into point vortices which condense into Si nanodroplets. At a low laser energy of similar to 1.2 J (0.23 GW/cm(2)), the inertial instability of nanodroplets under gradients of pressure and temperature, cause their intermittent accumulation Bafilomycin A1 in the low-pressure regions of turbulent field. The solidification of Si nanodroplets into particles and their redeposition, cause a simple two-dimensional low density nanostructuring of Si wafer in the near periphery region, and a high density nanostructuring in the periphery region of the spot. The pattern of redeposited Si nanoparticles

in these regions is equivalent to the pattern of point vortices in a two-dimensional turbulent field. Such a pattern of point vortices is obtained by numerical simulation from the two-dimensional CAL-101 price Navier-Stokes equation for forced turbulence. The self-organization of the coherent point vortex pattern is generated by numerical simulation of the solitary turbulence model based on the nonlinear Schroumldinger equation. At the high laser energy of similar to 1.5 and similar to 2.0 J (similar to 0.42 and similar to 0.52 GW/cm(2), respectively), the transition from simple intermittent two-dimensional nanoparticle organization into a continuous and more complex one takes place. The nanostructured pattern shows a continuous distribution of Si particles, whose size increases from the periphery toward the center without spatial intermittency, showing a gradient of particle size.