To counteract the effects of pathogenic cytokines in various chro

To counteract the effects of pathogenic cytokines in various chronic diseases, anticytokine Abs have been used either passively administered or induced by an active immunization. In some cancers, anti-VEGF mAbs used in association with chemotherapy

have proved to be therapeutically beneficial (2). Our group have prepared a VEGF immunogen, constituted by a KLH-VEGF heterocomplexe, termed VEGF kinoid. Active immunization of mice with the VEGF derivative immunogen, appropriately adjuvanted, proved to be fully innocuous and mounted selleck kinase inhibitor a high anti-VEGF neutralizing Ab titer but not a cellular response. Purified IgG from immune sera decreased by ≥50% tumor growth of human A673 rhabdomyosarcoma cells and HT29 colon carcinoma xenografted in Swiss nude and Nod/SCID mice respectively. Following active mVEGF kinoid immunization, Balb/c mice challenged with syngeneic CT26 colorectal tumor cells showed a reduced growth of metastases and a reduced

tumor Cell Cycle inhibitor AZD1480 ic50 vascularization but had no effect on the primary tumor cell growth (3). In cancer oxyclozanide treatments besides VEGF kinoid other kinoids targeting pathogenic cytokines could represent future medications as

TNFα kinoid (4) which is currently used in Crohn’s disease clinical trials. (1) Zagury D, et al. Cytokine Growth Factor Rev. 2003 14:123–37. (2) Escudier B, et al. Expert Rev Anticancer Ther. 2008 8:1545–57. (3) Rad FH, et al. PNAS. 2007 104:2837–42. (4) Le Buanec H, et al. PNAS. 2006 103:19442–7. O123 Comparative Uncovering of Tumors’ Systems Biology by Modular Targeting of Tumor-Associated Inflammation Albrecht Reichle 1 1 Hematology/Oncology, University Hospital Regensburg, Regensburg, Germany As yet, it is assumed that tumors defy experimental therapeutic access from inside in a comprehensive and reconstructive way (systems view) but only comply an observation-guided, contra-intuitive knowledge about biochemical pathways. Based on this familiar assumption the rational for new therapeutic strategies is commonly derived from theme-dependent context knowledge.

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