According to the position of reflux content reaching, GERD is divided into three degrees as light (barium reflux to the Lower esophagus); Moderate (reflux to the middle esophagus);

Severe (reflux to the upper esophagus). The patients data were retrospectively analyzed from January 2003 to December 2012 of GERD detection rate by barium meal, and relationship with gender, age, etc. And the degree, position of reflux during barium meal in 2012 patients with GERD were studied. Results: Detection rate of GERD was 13.48% (2743/20353 cases) in ten years of barium meal. The male detection rate was 13.73%, female 13.25%. GERD detection rate Among all age groups, with the increase of age, GERD detection rate is higher.

The mild reflux accounted for 53.30%, moderate was 24.23%, severe was 22.47% in patients with Selleckchem Liproxstatin 1 GERD in 2012. The position with left anterior oblique was most, accounting for 95.37%. Conclusion: Barium meal can be directly observed with and without gastroesophageal reflux, and evaluated the degree of reflux and position (the patients should be to avoid as far as possible the rest of this position). Method of barium meal is simple and intuitive, the result is similar with other methods, can be Navitoclax manufacturer used as one of GERD diagnostic method. Key Word(s): 1. Barium meal; 2. GERD; Presenting Author: CHENGWEI TANG Additional Authors: JING LI, YI XIE, FANG YUAN, BIN SONG Corresponding Author: CHENGWEI TANG Affiliations: Department of Gastroenterology, West China Hospital, Sichuan University; Department of Gastroenterology, West China Hospital, Sichuan University; Department of Radiology, West China Hospital, Sichuan University Objective: Accumulating animal studies and our previous clinical research showed that long-term alcohol administration led to pancreatic steatosis. But its possible genetic background

is still unclear. Alcohol-induced pancreatic steatosis is associated with alcohol metabolism in the pancreas, in which alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are the major oxidative enzyme. And genetic polymorphism of ADH2 and ALDH2 is known to be closely related to alcohol dependence. This study is to find out whether MCE genetic polymorphism of them is also relevant to pancreatic steatosis in alcoholics in order to reveal the possible genetic background of alcohol-induced pancreatic steatosis in alcoholics. Methods: 163 alcoholic male aged 20∼70 years with a normal body mass index were recruited into this study. The alcoholics were defined as the drinkers with an alcohol intake of >80 g/day, a duration of >5 years. They received magnetic resonance scanning in the epigastric region by using double-echo chemical shift magnetic resonance technique. PCR- restriction fragment length polymorphism was used for ADH2 and ALDH2 genotype detection.