“Dose 5” will increase the chances of seroconversion even if travelers

were not immune at clinic visit 3. In our travel medicine clinic, a significant number of travelers would not have been protected against rabies if the TRID2 vaccine schedule had not been offered to them. Taking into account the cost of the PD-0332991 cost vaccines and the number of clinic visits, the total cost of administering the TRID2 vaccine schedule is currently approximately the same as for the standard ID course. Variations in timing in the “TRID2 nonstandard” group were largely caused by travelers being busy with work or personal commitments at the time of the recommended clinic visit days, and these variations occurred more frequently during busy times such as Christmas and public holidays. In the real world, pretravel preparation of travelers often involves planning vaccine doses around other commitments, and it is reassuring to know that irregular timing of vaccine doses in the “TRID2 nonstandard” schedule in this case series did not affect immunogenicity. The overall seroconversion

rate of 98.3% after three clinic visits and five ID NVP-BKM120 doses is similar to the immunogenicity of the standard ID schedule found in studies in similar travel clinics in Australia and New Zealand, which have reported seroconversion rates of between 95.1 and 99.5%.6–8 At our Brisbane travel medicine clinic, 317 travelers received the standard ID schedule between 1999 and 2005. This series of travelers had a seroconversion rate of 99.4% (D Mills, personal

communication, April 2011), which is not statistically different to the 98.3% seroconversion achieved using TRID2 (p = 0.21). The seroconversion rate of 94.5% after two clinic visits of the TRID2 schedule is significantly lower than seroconversion rate with the standard ID schedule (p = Carnitine palmitoyltransferase II 0.00), but TRID2 has the advantage of providing earlier confirmation of immunity to travelers, and should be considered as an option in those departing in less than 7 weeks. A comparison of antibody levels measured after a standard ID course versus a TRID2 course showed that travelers who received a standard ID course had significantly higher antibody levels, with 74.5% having levels of >4.0 IU/mL (p = 0.00) at an average of 22 days after the third ID vaccine dose. However, the clinical significance of higher antibody levels is unclear, and it is difficult to make direct comparisons of levels because serology was performed at different times in the two groups. TRID2 was more effective in the younger age groups, inducing higher seroconversion rates as well as antibody levels. Over half (62.9%) of the travelers in this study were aged between 20 and 40 years of age, and larger numbers of cases are required to accurately assess the immunogenicity of the TRID2 schedule in other age groups.