The mean follow-up time was 320 days, the overall mortality rate was 62% and previous aspiration pneumonia (p = 0.006), higher levels of C-reactive protein (p = 0.002) and leucocytosis (p = 0.005) are among the predictive

factors of mortality found. The 30-day mortality rate was 19% and the only predictive factor of mortality found was higher urea levels (p = 0.046). Ninety-six BYL719 percent of patients had a follow-up period superior to 90-days and 91% superior to 180-days: mortality rates were 30% and 43%, respectively, and the predictive factors of mortality observed were: diabetes mellitus (90-days : p = 0.013;180-days : p = 0.040) and higher levels of C-reactive protein (90-days : p = 0.002; 180-days : p = 0.008). Conclusion: The mortality rate

after PEG placement is high. Past history of aspiration pneumonia, presence of diabetes mellitus and higher levels of C-reactive protein significantly influenced the prognosis of these patients. These factors should be considered in the decision making of PEG insertion. Key Word(s): 1. PEG; Presenting Author: ENQIANG LINGHU Additional Authors: YAQI ZHAI, HUIKAI LI, ZHICHU QIN, LIHUA PENG, XIAOLIN SHI, XIAOYU QIU, QIYANG HUANG, YONGWEI ZHAO Corresponding Author: ENQIANG LINGHU Affiliations: Department of Gastroenterology and Hepatology,The Chinese PLA General Hospital; Department of Gastroenterology and Hepatology,The PLA General Hospital GDC941 Objective: Peroral endoscopic myotomy (POEM) is a new-developed minimally invasive endoscopic technique, expected to be the first choice for achalasia (AC).Not only is POEM technically challenging and time consuming, but incidence of complications is fairly high,such as pneumoderm and even pneumothorax. Therefore, we have initially developed a new POEM with longitudinal entry incision to settle above-mentioned

上海皓元医药股份有限公司 problems.Our aim was to compare the safety and efficiency of transverse-incision POEM with longitudinal-incision POEM. Methods: This is a prospective controlled trial, but not randomized.POEM,with transverse or longitudinal entry incision, was performed on 53 consecutive patients confirmed achalasia (AC) between December 2010 and Septemper 2012. Data of those patients was recorded, including time in different procedures, complications. Results: All the 53 patients underwent POEM successfully, among whom 41 patients was performed with transverse entry incision and 12 for longitudinal incision. Treatment success (Eckardt score≤3), with a median 5 month follow-up,was achieved in 96.2 % of cases (mean score pre-treatment vs. post-treatment: 7.5 vs. 0.6,P < 0.001). The whole operation time of transverse-incision group is a little shorter than that of longitudinal-incision((65.0 ± 18.0)min vs (74.1 ± 18.2)min,P = 0.142). But it took much less time in the process of tunnel built-up and muscle dissection in the transverse-incision group((36.3 ± 9.0)min vs (45.4 ± 10.5)min; (10.2 ± 4.6)min vs 15.5 ± 5.5 min P < 0.05).