This is likely to occur because the exercise may increase myocardial collagen content (Bartosov et al., 1969 and Kiiskinen and Heikkinen, 1976), possibly due an increase in myocardial prolyl 4-hydroxylase, an enzyme with an activity level positively correlated with collagen biosynthesis (Takala et al., 1991 and Thomas et al., 2000). The ammoniacal silver technique evidences reticular fibers, which are rich on collagen type III. Through this technique it was possible to observe a light increase on the intensity of the SD group’s reaction when compared to the control Dolutegravir price groups (SC and
TC). This result shows that there might have occurred a deposition Z-VAD-FMK purchase of collagen type III on the animals
from SD group, represented by the fibers evidenced on the reaction, possibly due to an initial state of fibrosis that could have been developed and reached an advanced level, as Shimizu et al. (1993) observed on humans. However, the low specificity of this technique does not allow us to go on a deeper analysis about the type III collagen, one of the components most affected by diabetes. Based on the results observed, it is possible to conclude that the regular practice of physical exercises might have an important role on the prevention, or even the re-establishment, of some of the negative alterations caused by diabetes on animal models. However, studies that involve morphological, biochemical and molecular alterations still are necessary for the complete understanding of changes caused by these complex metabolic disorders that characterize diabetes. The authors thank Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES-Brazil) for the
financial support. Also we thank Eliete Luciano for performing the experimental diabetes induction and to José Alexandre C. A. Leme for the great help. “
“Oenocytes are cells of ectodermal origin that may be associated with the epidermis or distributed amongst insect Cediranib (AZD2171) fat body cells. The distribution and association to the epidermis may depend on insect species or developmental stage. Due to their localization in the hemocele, large size and uncommon morphology, oenocytes have previously attracted the attention of insect physiologists. Typically, they have been considered analogous to the vertebrate steroidogenic cells specialized in fatty acids synthesis (Dean et al., 1985, Wigglesworth, 1988, Haunerland and Shirk, 1995, Gould et al., 2001 and Rollo and Camargo-Mathias, 2006). Primary cultures of insect oenocytes have helped unravel, at least in part, the functions of these cells in many insects. For instance, Romer et al.