Masuhara et al. applied TDM-621 to 33 vascular anastomotic graft sites and reported that the efficacy rate was 94.5% and no postoperative bleeding and adverse events were observed. The present study Nutlin 3a supports the efficacy and safety of TDM-621 and shows clinical appreciation to the endoscopic treatments. However,
TDM-621 was applied to the oozing only. The next question is whether TDM-621 is effective against more active bleeding or not. It was shown that hemostasis using TDM-621 was feasible after endoscopic treatments of the gastric tumors without any technical trouble or adverse event. Further studies with a large number of patients are required to confirm it. “
“Presenting Author: PAVELMIHAJLOVICH KOSENKO Additional Authors: SERGEYANDREEVICH VAVRINCHUK Corresponding Author: PAVELMIHAJLOVICH
KOSENKO Affiliations: Far Eastern State Medical University; postgraduate institute for public health workers Objective: Study objective – to study the age related particularities of electrogastroenterography (EGEG) parameters and its effect on electrophysiological evaluation of gastrointestinal motor function. Methods: The study involved 15 young (age 18–23 years) and 15 old (age 69–75 Proteases inhibitor years) practically healthy people. The criteria of inclusion of the study were the absence of organic and functional gastrointestinal diseases in the anamnesis. To evaluate the gastrointestinal tract motor functions we used EGEG method with evaluation of parameters for basal and stimulated electric activity (EA) of gastrointestinal sections. Standard food load was used as the stimulator of GMF. We used the following parameters: Ps (mV) – total level of gastrointestinal EA; Pi (mV) – EA by gastrointestinal Dimethyl sulfoxide sections, Pi/Ps (%) – rate of each frequency spectrum in total spectrum; Кrhythm – ratio of spectrum curve to the length of spectrum part for studied, Pi/P (i + 1) – ratio of
EA of superior gastrointestinal section to inferior. Results: When comparing the EGEG parameters in two groups using Mann – Whitney U-test we found no statistically significant differences between groups of old and young people. Using the discrimination analysis (DA) we detected 5 variables in which the groups of young and old studied people possessed statistically significant differences. The parameters involved basal parameters – Pi of colon, Pi/Ps of stomach, Pi/P (i + 1) jejunum/ileum, Кrhythm of duodenum and colon, as well as stimulated parameters – Pi/Ps of duodenum and Pi/P (i + 1) duodenum/jejunum. Based on the DA we created the mathematical models of duodenal stenosis. Use of detected age-related particularities of EGEG parameters allowed us to increase the accuracy of proposed distribution of patients with stenosis from 85.2% to 92.8%. Conclusion: Thus there are the age-relevant particularities of EGEG parameters that need to be taken in account during interpretation of the results of electro-physiological evaluation of GMF. Key Word(s): 1. electrophysiology; 2. electrogastrography; 3.